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SOUHRN  \'daDAJ\'d9  O  P\'d8\'cdPRAVKU  (SPC)
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\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \b\insrsid947691 N\'c1ZEV VETERIN\'c1RN\'cdHO  L\'c9\'c8IV\'c9HO  P\'d8\'cdPRAVKU
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 MARBOCYL FD 10 mg/ml lyofiliz\'e1t }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1248631 a rozpou\'9at\'ecdlo }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid947691 pro p\'f8\'edpravu injek\'e8n\'edho roztoku}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15561032 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 P\'f8\'edpravek s\~indika\'e8n\'edm omezen\'edm.
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\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \b\insrsid947691 KVALITATIVN\'cd A KVANTITATIVN\'cd  SLO\'8eEN\'cd
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{\*\xmlopen\xmlns2{\factoidname metricconverter}{\xmlattr\xmlattrns0{\xmlattrname ProductID}{\xmlattrvalue 1 g}}}1 g{\*\xmlclose} lyofiliz\'e1tu obsahuje:
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid947691 L\'e9\'e8iv\'e1 l\'e1tka  :
\par }\pard\plain \ltrpar\s2\ql \li0\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel1\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid947691 Marbofloxacinum                  200,0 mg
\par }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid947691 Pomocn\'e9 l\'e1tky
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 Benzalkonium chlorid \tab 2,0 mg
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 \'dapln\'fd seznam pomocn\'fdch l\'e1tek viz bod 6.1.
\par 
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\ul\insrsid947691 1 ml rozpou\'9at\'ecdla obsahuje}{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\ul\insrsid11932807 :}{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\ul\insrsid947691 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 Voda na injekci\tab 1 ml
\par 
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\ul\insrsid947691\charrsid11932807 1 ml rekonstituovan\'e9ho lyofiliz\'e1tu obsahuje:
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid947691 L\'e9\'e8iv\'e1 l\'e1tka  :
\par }\pard\plain \ltrpar\s2\ql \li0\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel1\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid947691 Marbofloxacinum                  10 mg
\par }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid947691 Pomocn\'e9 l\'e1tky
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 Benzalkonium chlorid \tab 0,1 mg
\par }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid947691 
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\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst2\pnrxst0\pnrxst0\pnrxst0\pnrxst46\pnrxst0\pnrstop6\pnrstart1\pnrrgb1\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9\pnrstart2\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0
\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc3\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr3\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \b\insrsid947691 L\'c9KOV\'c1 FORMA
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Lyofiliz\'e1t }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1248631 a rozpou\'9at\'ecdlo }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid947691 pro p\'f8\'edpravu injek\'e8n\'edho roztoku 
\par P\'f8ed rekonstituc\'ed: b\'edl\'e1 a\'9e sv\'ectle \'9elut\'e1 lyofilizovan\'e1 tableta
\par Po rekonstituci: \'e8ir\'fd sv\'ectle \'9elut\'fd roztok
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\ul\insrsid947691 4}{\rtlch\fcs1 \af0 \ltrch\fcs0 \ul\insrsid947691 .}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\ul\insrsid947691  KLINICK\'c9 \'daDAJE
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\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst3\pnrxst0\pnrxst0\pnrxst0\pnrxst46\pnrxst0\pnrxst1\pnrxst0\pnrstop8\pnrstart1\pnrrgb1\pnrrgb3\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9
\pnrstart2\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc4\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc1\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr4\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr1\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrstop36\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 C\'edlov\'fd druh zv\'ed\'f8at
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Ko\'e8ka a pes.
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.2  Indikace
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2824705 L\'e9\'e8ba infekc\'ed zp\'f9soben\'fdch z\'e1rodky citliv\'fdmi na marbofloxacin:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2824705\charrsid2824705 
\par }{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\insrsid947691 Ko\'e8ka:
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid1123249 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 -}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid11691032  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
l\'e9\'e8ba}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 infikovan\'fdch ran a absces\'f9}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\i\insrsid1123249\charrsid5452580 Pasteurella multocida}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580 ,  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid5452580 Staphylococcus intermedius}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1123249\charrsid5452580 , }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid5452580 Staphylococcus aureus, Staphylococcus}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580  sp}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249 p}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580 ., }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid5452580 Enterobacter}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580  s}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1123249 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580 p. and }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid5452580 Klebsiella}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580  s}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1123249 p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580 p.
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid1123249 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11691032  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249 v od\'f9
vodn\'ecn\'fdch p\'f8\'edpadech jako p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1124939 eriopera\'e8n\'ed profylaxe}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1124939 chr\'e1n\'edc\'ed p\'f8ed }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1123249 postopera\'e8n\'edmi infekcemi zp\'f9soben\'fdmi z\'e1rodky, pro kter\'e9 je marbofloxacin l\'e9kem volby.
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid947691 
\par 
\par }{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\insrsid947691 Pes:
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid1123249 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11691032  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 l\'e9\'e8
ba}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 infikovan\'fdch ran a absces\'f9}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid14626062 
Staphylococcus intermedius}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid14626062 , }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid14626062 Staphylococcus aureus}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid14626062 , }{
\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid14626062 Escherichia coli}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid14626062 , }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid14626062 Pasteurella }{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1123249\charrsid5452580 spp}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid14626062 . and }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid1123249\charrsid14626062 Pseudomonas }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1123249\charrsid5452580 spp.}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11691032  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 infek\'e8n\'ed onemocn\'ecn\'ed  mo\'e8ov\'fdch cest zp\'f9soben\'e1 }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid947691 Escherichia coli a Proteus mirabilis

\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid1385856 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\delrsid5452580  }{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid1385856 v od\'f9vodn\'ecn\'fdch p\'f8\'edpadech jako periopera\'e8n\'ed profylaxe chr\'e1n\'edc\'ed p\'f8ed postopera\'e8n\'edmi infekcemi zp\'f9soben\'fdmi z\'e1rodky, pro kter\'e9 je marbofloxacin l\'e9kem volby.
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid1123249 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1385856 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249\charrsid5452580 Marbofloxacin je ne\'fa\'e8inn\'fd na anaerobn\'ed infekce}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1123249 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.3  Kontraindikace
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 U \'9at\'ec\'f2at velk\'fdch a velmi velk\'fdch plemen  v\~p\'f8\'edpadech dlouhodob\'e9 l\'e9\'e8by fluorochinolony se m\'f9\'9ee vyskytnout po\'9akozen\'ed (eroze) kloubn\'edch chrupavek, proto se u \'9at
\'ec\'f2at velk\'fdch plemen do st\'e1\'f8\'ed 12 m\'ecs\'edc\'f9, resp. u \'9at\'ec\'f2at velmi velk\'fdch plemen do st\'e1\'f8\'ed 18 m\'ecs\'edc\'f9 nedoporu\'e8uje MARBOCYL FD aplikovat.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.4  Zvl\'e1\'9atn\'ed upozorn\'ecn\'ed pro ka\'9ed\'fd c\'edlov\'fd druh
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Nejsou.
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.5  Zvl\'e1\'9atn\'ed opat\'f8en\'ed pro pou\'9eit\'ed
\par Zvl\'e1\'9atn\'ed opat\'f8en\'ed pro pou\'9eit\'ed u zv\'ed\'f8at}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1123249 
\par }\pard\plain \ltrpar\ql \li0\ri0\sl240\slmult0\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid1123249 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\insrsid1123249 P\'f8i pou\'9eit\'ed p\'f8\'edpravku je nutno vz\'edt v \'favahu ofici\'e1ln\'ed a m\'edstn\'ed pravidla antibiotick\'e9 politiky. 
\par Doporu\'e8uje se ponechat fluorochinolony na l\'e9\'e8bu klinick\'fdch stav\'f9, kter\'e9 m\'ecly slabou odezvu,
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid1123249 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid1123249 nebo se o\'e8ek\'e1v\'e1 slab\'e1 odezva na ostatn\'ed skupiny antibiotik.
\par }\pard \ltrpar\ql \li0\ri0\sl240\slmult0\widctlpar\wrapdefault\faauto\rin0\lin0\itap0\pararsid1123249 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid1123249 Pou\'9eit\'ed fluorochinolon\'f9 by m\'eclo b\'fdt v\'9edy, kdy\'9e je to mo\'9en\'e9, zalo\'9e
eno na v\'fdsledku testu citlivosti. 
\par Pou\'9eit\'ed p\'f8\'edpravku, kter\'e9 je odli\'9an\'e9 od pokyn\'f9 uveden\'fdch v tomto souhrnu \'fadaj\'f9 o p\'f8\'edpravku (SPC), m\'f9\'9ee zv\'fd\'9ait prevalenci bakteri\'ed rezistentn\'edch na fluorochinolony a sn\'ed\'9eit \'fa\'e8
innost terapie ostatn\'edmi chinolony z\~d\'f9vodu mo\'9en\'e9 zk\'f8\'ed\'9een\'e9 rezistence.  }{\rtlch\fcs1 \af5\afs24 \ltrch\fcs0 \f5\fs24\insrsid1123249  
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
Fluorochinolony mohou p\'f8i vysok\'fdch d\'e1vk\'e1ch p\'f9sobit na p\'f9vodce epileptick\'fdch z\'e1chvat\'f9 a na srde\'e8n\'ed - ob\'echov\'fd syst\'e9m mohou m\'edt oslabuj\'edc\'ed vliv. P\'f8ed o\'9aet\'f8en\'edm zv\'ed\'f8at, kter\'e1 m\'ecla v\~
minulosti epileptick\'e9 z\'e1chvaty nebo kardiovaskul\'e1rn\'ed poruchy, se mus\'ed prov\'e9st p\'f8edopera\'e8n\'ed vy\'9aet\'f8en\'ed. Experiment\'e1ln\'ec nevykazoval marbofloxacin \'9e\'e1dn\'e9 epileptick\'e9 reakce u ps\'f9 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid1123249 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 Zvl\'e1\'9atn\'ed  opat\'f8en\'ed ur\'e8en\'e9 osob\'e1m, kter\'e9 pod\'e1vaj\'ed veterin\'e1rn\'ed l\'e9\'e8iv\'fd p\'f8\'edpravek zv\'ed\'f8at\'f9m
\par }\pard\plain \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid15800343 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\insrsid15800343\charrsid15800343 Po pou\'9eit\'ed p\'f8\'edpravku si umyjte ruce.
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid15800343\charrsid15800343 Zabra\'f2te kontaktu p\'f8\'edpravku s\~poko\'9ekou a o\'e8ima. }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf2\insrsid15800343\charrsid15800343 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid15800343\charrsid15800343 V\~p\'f8\'edpad\'ec pot\'f8\'edsn\'ecn\'ed poko\'9eky p\'f8\'edpravkem opl\'e1chn\'ecte zasa\'9eenou \'e8\'e1st }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\insrsid15800343\charrsid15800343 velk\'fdm mno\'9estv\'edm pitn\'e9 vody}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid15800343\charrsid15800343 . }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid15800343\charrsid15800343 V\~p\'f8\'edpad\'ec
 zasa\'9een\'ed o\'e8\'ed vypl\'e1chn\'ecte exponovan\'e9 oko }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid15800343\charrsid15800343 proudem \'e8ist\'e9 vody}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid15800343\charrsid15800343 
. Pokud se dostav\'ed pot\'ed\'9ee, vyhledejte l\'e9ka\'f8skou pomoc.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf2\insrsid15800343\charrsid15800343 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid15800343\charrsid15800343 P\'f8edch\'e1zejte n\'e1hodn\'e9mu samopod\'e1n\'ed injekce. Chra\'f2te jehlu a\'9e do okam\'9eiku pod\'e1n\'ed p\'f8\'edpravku. V\~p\'f8\'edpad\'ec n\'e1hodn\'e9ho sebepo\'9a
kozen\'ed injek\'e8n\'ec aplikovan\'fdm p\'f8\'edpravkem, vyhledejte l\'e9ka\'f8skou pomoc a uka\'9ete p\'f8\'edbalovou informaci nebo etiketu o\'9aet\'f8uj\'edc\'edmu l\'e9ka\'f8i.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf2\insrsid15800343\charrsid15800343 
\par }\pard \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid15800343\charrsid15800343 Lid\'e9 se zn\'e1mou p\'f8ecitliv\'eclost\'ed na fluorochinolony by se m\'ec
li vyhnout kontaktu s\~veterin\'e1rn\'edm l\'e9\'e8iv\'fdm p\'f8\'edpravkem.}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf1\insrsid947691 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.6  Ne
\'9e\'e1douc\'ed \'fa\'e8inky
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Zcela vz\'e1cn\'ec se u ps\'f9 mohou vyskytnout vedlej\'9a\'ed \'fa\'e8inky jako zvracen\'ed, salivace a bolest v\~m\'edst\'ec aplikace. U ko\'e8ek se m\'f9\'9ee pozorovat slin\'ecn\'ed. Tyto symptomy spont
\'e1nn\'ec odejdou.
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16217000 Po subkut\'e1nn\'edm pod\'e1n\'ed dvojn\'e1sobn\'e9 doporu\'e8en\'e9 d\'e1vky u psa nebo trojn\'e1sobn\'e9 doporu\'e8en\'e9 d\'e1vky }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 u ko\'e8ky nebyly pozorov
\'e1ny vedlej\'9a\'ed \'fa\'e8inky. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 Po i.v. pod\'e1n\'ed 4mg/kg byly hl\'e1\'9aeny vz\'e1cn\'ec m\'edrn\'e9 a p\'f8echodn\'e9 \'fa\'e8inky: 
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 \hich\af0\dbch\af0\loch\f0 -\tab}}\pard \ltrpar\s19\qj \fi-360\li720\ri0\widctlpar\wrapdefault\faauto\ls13
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst1\pnrxst0\pnrxst45\pnrxst0\pnrstop4\pnrstart1\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9\pnrstart2\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23
\pnrnfc23\pnrnfc23\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin720\itap0\pararsid1449355 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 Slinivost (nadm\'ecrn\'e1 salivace)
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 \hich\af0\dbch\af0\loch\f0 -\tab}}\pard \ltrpar\s19\qj \fi-360\li720\ri0\widctlpar\wrapdefault\faauto\ls13
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst1\pnrxst0\pnrxst45\pnrxst0\pnrstop4\pnrstart1\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9\pnrstart2\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23
\pnrnfc23\pnrnfc23\pnrnfc0\pnrnfc0\pnrnfc1\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr1\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin720\itap0\pararsid16401713 {
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 Nervov\'e9 poruchy (vyd\'e1v\'e1n\'ed }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16401713 zvuku}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355 )}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16401713 , d}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid1449355 r\'e1\'9ed\'ecn\'ed, chv\'ecn\'ed (myoclonia)
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16217000 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.7   Pou\'9e\'edv\'e1n\'ed v\~pr\'f9b\'echu gravidity a laktace
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Studie na laboratorn\'edch zv\'ed\'f8atech (potkan, kr\'e1l\'edk) nevyk\'e1zaly p\'f8i pou\'9e\'edv\'e1n\'ed terapeutick\'fdch d\'e1vek teratogenn\'ed, embryotoxick\'e9 \'e8i maternotoxick\'e9 vlivy. Nez\'e1
vadnost l\'e9ku u ko\'e8ek a fen b\'echem b\'f8ezosti a laktace nebyla dokazov\'e1na. P\'f8\'edpravek by se nem\'ecl u fen b\'echem b\'f8ezosti a laktace pou\'9e\'edvat, pop\'f8. pouze na vlastn\'ed riziko veterin\'e1rn\'edho l\'e9ka\'f8e.
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.8  Interakce s\~jin\'fdmi veterin\'e1rn\'edmi l\'e9\'e8iv\'fdmi p\'f8\'edpravky
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Studie u ps\'f9 neuk\'e1zaly zm\'ecnu \'fa\'e8inku marbofloxacinu p\'f8i pou\'9eit\'ed spolu s\~anestetiky jako je isofluran a kombinace medetomidinu/ketaminu.
\par 
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 \hich\af0\dbch\af0\loch\f0 4.9\tab}}\pard \ltrpar\s19\qj \fi-480\li480\ri0\widctlpar\jclisttab\tx480\wrapdefault\faauto\ls14\ilvl1
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst3\pnrxst0\pnrxst0\pnrxst0\pnrxst46\pnrxst0\pnrxst1\pnrxst0\pnrstop8\pnrstart1\pnrrgb1\pnrrgb3\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9
\pnrstart2\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc4\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc9\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr4\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr9\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrstop36\adjustright\rin0\lin480\itap0\pararsid11691032 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 D\'e1vkov\'e1n\'ed a zp\'f9sob pod\'e1n\'ed
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid11691032 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid11691032 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\ul\insrsid1449355\charrsid11691032 Rekonstituce}{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\ul\insrsid1449355\charrsid11691032 :}{
\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\ul\insrsid1123249\charrsid11691032 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5584845\charrsid11691032 P\'f8ed pou\'9eit\'edm prove\'efte rekonstituci lyofiliz\'e1tu pomoci \'f8edidla (voda pro injekci) v\~200mg lahvi\'e8ce. Asepticky p\'f8idejte 20 ml rozpou\'9at\'ec}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid16191999 d}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5584845\charrsid11691032 la do lyofiliz\'e1tu. T\'edmt}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16191999 o}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5584845\charrsid11691032  zp\'f9sobem z\'ed
sk\'e1te roztok, kter\'fd obsahuje 10mg marbofloxacinu v\~1 ml. }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid1449355\charrsid11691032 
\par }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid11691032\charrsid11691032 
\par }{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\ul\insrsid947691 Pes:}{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\insrsid947691   
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16191999  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid947691 o\'9aet\'f8en\'ed infikovan\'fdch ran a absces\'f9:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  
2 mg marbofloxacinu/kg \'9e.hm./den jednor\'e1zov\'ec subkut\'e1nn\'ec, pot\'e9 pokra\'e8ovat v\~aplikaci MARBOCYL tablety po 6 dn\'f9
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7291856 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid9731508 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16191999  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid947691 o\'9a
et\'f8en\'ed p\'f8i infekci mo\'e8ov\'fdch cest:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9731508\charrsid9731508 4 mg marbofloxacinu/kg \'9e.hm./den ve 3 subkut\'e1nn\'edch injekc\'edch v\~rozmez\'ed 4 dn\'f9

\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \highlight7\insrsid11691032 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691\charrsid7675391 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid13375680\charrsid7675391  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid13375680\charrsid7675391 periopera\'e8n\'ed profylaxe}{\rtlch\fcs1 \ai\af0 
\ltrch\fcs0 \i\insrsid947691\charrsid7675391 :}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691\charrsid7675391  2 mg marbofloxacinu/kg \'9e.hm./den jako jednor\'e1zov\'e1 intraven\'f3zn\'ed aplikace p\'f8\'edmo p\'f8ed chirurgick\'fdm z\'e1krokem}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5584845   }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid7675391 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }{\rtlch\fcs1 \ab\ai\af0 \ltrch\fcs0 \b\i\ul\insrsid947691 Ko\'e8ka:
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid16191999  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 o\'9aet\'f8en\'ed infikovan\'fdch ran a absces\'f9:  2 mg marbofloxacinu/kg \'9e.hm./den subkut\'e1nn\'ec po 3 a
\'9e 5 dn\'f9
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11691032 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691\charrsid7675391 -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11691032\charrsid7675391  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid11691032\charrsid7675391 p}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\i\insrsid13375680\charrsid7675391 eriopera\'e8n\'ed profylaxe}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid947691\charrsid7675391 :}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691\charrsid7675391  2 mg marbofloxacinu/kg \'9e.hm./den jako jednor\'e1zov\'e1
 intraven\'f3zn\'ed aplikace }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid5584845\charrsid7675391  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 Zp\'f9sob pod\'e1v\'e1n\'ed
\par }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid947691 Ko\'e8ka, pes:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691                 s.c., i.v.
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.10   P\'f8ed\'e1vkov\'e1n\'ed}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  (symptomy, opat\'f8en\'ed, antidota)
\par P\'f8i p\'f8ed\'e1vkov\'e1n\'ed se mohou pozorovat symptomy neurologick\'e9ho charakteru:
\par Salivace, slzen\'ed, t\'f8es, myoklonie a k\'f8e\'e8e. V\~p\'f8\'edpad\'ec t\'ec\'9ek\'fdch reakc\'ed je t\'f8eba zav\'e9st symptomatickou l\'e9\'e8bu. T\'e9\'9e byla pozorov\'e1na bradykardie.
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 4.11  Ochrann\'e9 lh\'f9ty
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Nen\'ed ur\'e8eno pro potravinov\'e1 zv\'ed\'f8ata.
\par 
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid9731508 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\ul\insrsid947691 5.  FARMAKOLOGICK\'c9 VLASTNOSTI
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Farmakoterapeutick\'e1 skupina: }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid15800343 Fluorochinolony,}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par ATCvet k\'f3d: QJ01MA93
\par }{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\ul\insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 5.1. Farmakodynamick\'e9 vlastnosti
\par }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691 Marbofloxacin je syntetick\'e9 baktericidn\'ed antiinfektivum pat\'f8\'edc\'ed do skupiny fluorochinolon\'f9. Mechanismem jeho \'fa\'e8inku je inhibice DNA-gyr\'e1zy. Jeho \'9airok\'e9 spektrum \'fa
\'e8inku zahrnuj\'ed grampozitivn\'ed bakterie (p\'f8edev\'9a\'edm }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 Staphylococcus }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \ai\af0\afs22 
\ltrch\fcs0 \i\fs22\insrsid947691  a Streptococcus }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 )}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691 
, gramnegativn\'ed bakterie (zvl\'e1\'9at\'ec }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 Escherichia coli, Salmonella typhimurium, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Proteus }{
\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 , Klebsiella }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 
\ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 , Shigella }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 ,  Pasteurella }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691 , }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 Haemophilus }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{
\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 , Moraxella }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 , Pseudomonas }{\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\insrsid947691\charrsid11357506 spp.}{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 ,}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691  }{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\insrsid947691 Brucella canis}{
\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\insrsid947691 ) a mykoplasmata.
\par 
\par }\pard\plain \ltrpar\qc \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3146785 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \ab\af0\afs24 
\ltrch\fcs0 \b\fs24\insrsid3146785\charrsid10049941 \'da\'e8innost marbofloxacinu na kmeny patogen\'f9 zv\'ed\'f8at data z EU 2006
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3146785 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid3146785\charrsid10049941 
\par \ltrrow}\trowd \irow0\irowband0\ltrrow\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol
\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil \cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl 
\clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\pard \ltrpar
\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\lang2057\langfe1029\langnp2057\insrsid11357506\charrsid10049941 Kmeny}{\rtlch\fcs1 \ab\af0\afs24 
\ltrch\fcs0 \b\fs24\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \cell }\pard \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 
\b\fs24\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 Nb\cell Min MIC
\par (\'b5g/ml)\cell Max MIC
\par (\'b5g/ml)\cell MIC}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\lang2057\langfe1029\sub\langnp2057\insrsid3146785\charrsid10049941 50}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \cell 
MIC}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\lang2057\langfe1029\sub\langnp2057\insrsid3146785\charrsid10049941 90}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \cell % Susc.\cell 
}\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \trowd \irow0\irowband0\ltrrow
\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt
\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil 
\cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\row \ltrrow}\pard \ltrpar
\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang1040\langfe1029\langnp1040\insrsid3146785\charrsid11691032 Enterobacteriaceae
\par }\pard \ltrpar\qj \li367\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin367\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang1040\langfe1029\langnp1040\insrsid3146785\charrsid11691032 Escherichia coli
\par }\pard \ltrpar\qj \li607\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin607\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang1040\langfe1029\langnp1040\insrsid11357506\charrsid11691032 Z infekc\'ed mo\'e8ov\'e9
ho traktu}{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang1040\langfe1029\langnp1040\insrsid3146785\charrsid11691032 
\par }\pard \ltrpar\qj \li361\ri-191\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin-191\lin361\pararsid11357506 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang1036\langfe1029\langnp1036\insrsid3146785\charrsid10049941 Proteus spp
\par }\pard \ltrpar\qj \li601\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin601\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 Proteus mirabilis\cell 
}\pard \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang1036\langfe1029\langnp1036\insrsid3146785\charrsid10049941 95
\par 64
\par 47
\par 24
\par 17\cell 0.008
\par 0.008
\par 0.008
\par 0.03
\par 0.03\cell 8
\par 8
\par 8
\par 0.25
\par 0.12\cell 0.032
\par 0.024
\par 0.024
\par 0.044
\par 0.058\cell 0.386
\par 0.758
\par 0.443
\par 0.074
\par 0.058\cell 93.7
\par 90.6
\par 93.6
\par 100
\par 100\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang1036\langfe1029\langnp1036\insrsid3146785\charrsid10049941 \trowd \irow1\irowband1\ltrrow
\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt
\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil 
\cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\row \ltrrow}\pard \ltrpar
\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang1040\langfe1029\langnp1040\insrsid3146785\charrsid11691032 Pasteurella multocida
\par }\pard \ltrpar\qj \li330\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin330\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang1040\langfe1029\langnp1040\insrsid11357506\charrsid10049941 Z infekc\'ed respira\'e8n\'ed
ho traktu }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang1040\langfe1029\langnp1040\insrsid3146785\charrsid10049941 \cell }\pard \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 
\af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 49
\par 28\cell 0.008
\par 0.015\cell 0.12
\par 0.06\cell 0.016
\par 0.012\cell 0.035
\par 0.037\cell 100
\par 100\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \trowd \irow2\irowband2\ltrrow
\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt
\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil 
\cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\row \ltrrow}\pard \ltrpar
\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 Pseudomonas aeruginosa
\par }\pard \ltrpar\qj \li361\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin361\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid11357506\charrsid10049941 Z o}{\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 titis
\par }{\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid11357506\charrsid10049941 Z infekc\'ed respira\'e8n\'edho traktu}{\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 
\i\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \cell }\pard \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 85
\par 53
\par 17\cell 0.12
\par 0.12
\par -\cell 256
\par 32
\par -\cell 0.378
\par 0.403
\par -\cell 4.757
\par 5.816
\par -\cell 82.4
\par 77.4
\par 94.1\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \trowd \irow3\irowband3\ltrrow
\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt
\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil 
\cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\row \ltrrow}\pard \ltrpar
\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 Staphylococcus intermedius
\par }\pard \ltrpar\qj \li360\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin360\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid11357506\charrsid10049941 Z infekc\'ed k\'f9\'9ee

\par }\pard \ltrpar\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid11357506 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid11357506\charrsid11691032        Z infekc\'ed mo\'e8ov\'e9
ho traktu
\par }\pard \ltrpar\qj \li360\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin360\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid11357506\charrsid10049941 Z }{\rtlch\fcs1 \af0\afs22 
\ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 otitis\cell }\pard \ltrpar\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 
\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 57
\par 24
\par 11
\par 16\cell 0.12
\par 0.25
\par 0.25
\par 0.12\cell 32
\par 32
\par 1
\par 1\cell 0.191
\par 0.193
\par 0.202
\par 0.187\cell 0.428
\par 0.483
\par 0.435
\par 0.435\cell 98.2
\par 100
\par 90.9
\par 100\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 \trowd \irow4\irowband4\ltrrow
\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl 
\clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt
\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil 
\cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\row \ltrrow}\pard \ltrpar
\qj \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \ai\af0\afs22 \ltrch\fcs0 \i\fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 Staphylococcus aureus\cell }\pard \ltrpar
\qc \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\pararsid4867492 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 33\cell 0.12\cell 64\cell 0.235\cell 12.996
\cell 87.9\cell }\pard \ltrpar\ql \li0\ri0\widctlpar\intbl\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid10049941 
\trowd \irow5\irowband5\lastrow \ltrrow\ts11\trgaph70\trleft-108\trftsWidth3\trwWidth9385\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol
\tblind0\tblindtype3 \clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth3227\clshdrawnil \cellx3119\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl 
\cltxlrtb\clftsWidth3\clwWidth630\clshdrawnil \cellx3749\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1239\clshdrawnil \cellx4988\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl 
\clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1279\clshdrawnil \cellx6267\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx7217\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl 
\clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth950\clshdrawnil \cellx8167\clvertalt\clbrdrt\brdrtbl \clbrdrl\brdrtbl \clbrdrb\brdrtbl \clbrdrr\brdrtbl \cltxlrtb\clftsWidth3\clwWidth1110\clshdrawnil \cellx9277\row }\pard \ltrpar
\qj \li0\ri0\widctlpar\wrapdefault\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3146785 {\rtlch\fcs1 \af0\afs22 \ltrch\fcs0 \fs22\cf9\lang2057\langfe1029\langnp2057\insrsid3146785\charrsid11357506 
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid3146785 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid3146785 Patogeny s\~MIC \u8804\'3f 1 \'b5g/ml jsou citliv\'e9 na marbofloxacin zat\'edmco patogeny s MIC  \u8805\'3f 4 \'b5g/ml jsou rezistentn\'ed k\~marbofloxacinu.
\par }\pard\plain \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid3146785 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\cf9\insrsid3146785 
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid14905235 {\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\insrsid14905235\charrsid12222016 MIC marbofloxacinu distribuovan\'e9 podle indikovan\'fdch patogen\'f9

\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\ul\insrsid14905235\charrsid12222016 Infekce k\'f9\'9ee}{\rtlch\fcs1 \ab\af0\afs24 \ltrch\fcs0 \b\fs24\insrsid14905235\charrsid12222016 :
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 61 patogen\'f9 bylo izolov\'e1no z\~infekc\'ed k\'f9\'9ee. Nej\'e8ast\'ecji byly izolov\'e1ny }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 
Staphylococcus intermedius}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016  (24), }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Staphylococcus aureus }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\insrsid14905235\charrsid12222016 (17) a }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Pasteurella multocida}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016  (6).
\par Tyto patogeny vykazovaly  multimod\'e1ln\'ed  MIC distribuci pro marbofloxacin se 4 subpopulacemi:  subpopulace  0.015 - 0.12 \'b5g/ml s mod\'e1ln\'ed t\'f8\'eddou  0003 \'b5g/ml, hlavn\'ed populace mezi 0.25 - 1 \'b5g/ml s mod\'e1ln\'ed t\'f8\'ed
dou  0.25 \'b5g/ml, t\'f8et\'ed  subpopulace  rezistentn\'ed mezi 8 - 564 \'b5g/ml a jedna populace velmi  rezistentn\'ed > 256 \'b5g/ml. 
\par Na\~marbofloxacin citliv\'fdch bylo 90.2 % (55) izolovan\'fdch patogen\'f9 a rezistentn\'edch bylo 9.8% kmen\'f9 (6 patogen\'f9: 4 }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 S. aureus}{\rtlch\fcs1 \af0\afs24 
\ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 , 1 }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 P. aeruginosa}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016  and 1 }{\rtlch\fcs1 
\ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 E. coli}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 ). 
\par 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\ul\insrsid14905235\charrsid12222016 Infekce mo\'e8ov\'fdch cest}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 :
\par 80 patogen\'f9 bylo izolov\'e1no z infekce mo\'e8ov\'fdch cest. Nej\'e8ast\'ecji byly izolov\'e1ny }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Escherichia coli}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\insrsid14905235\charrsid12222016  (47), }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Staphylococcus intermedius}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016  (11) a }{\rtlch\fcs1 
\ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Proteus mirabilis}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016  (8).
\par Tyto patogeny vykazovaly  multimod\'e1ln\'ed  MIC distribuci marbofloxacinu - hlavn\'ed subpopulace 0.03 \'b5g/ml, druh\'e1  0.25 \'b5g/ml, t\'f8et\'ed  subpopulac\'ed  8 \'b5g/ml a posledn\'ed  subpopulaci  32 \'b5
g/ml reprezentovanou 1 patogenem (1.3%). Na marbofloxacin citliv\'fdch bylo 95% (76) z izolovan\'fdch patogen\'f9 a rezistentn\'edch bylo 5% kmen\'f9 (4 patogeny byly rezistentn\'ed).
\par 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\ul\insrsid14905235\charrsid12222016 Respira\'e8n\'ed infekce}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 :
\par 95 patogen\'f9 bylo izolov\'e1no z respira\'e8n\'edch infekc\'ed. }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Pasteurella multocida}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016  (28), }{
\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 \i\fs24\insrsid14905235\charrsid12222016 Bordetella bronchiseptica }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 (33), a }{\rtlch\fcs1 \ai\af0\afs24 \ltrch\fcs0 
\i\fs24\insrsid14905235\charrsid12222016 Pseudomonas aeruginosa }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid14905235\charrsid12222016 (17) byly nej\'e8ast\'ecji izolovan\'fdmi patogeny.
\par Tyto patogeny vykazovaly  bimod\'e1ln\'ed MIC distribuci - prvn\'ed populace  0.015 - 0.06 \'b5g/ml s mod\'e1ln\'ed t\'f8\'eddou  0.015 \'b5g/ml a jednu hlavn\'ed populaci   0.12 - 4 \'b5g/ml s mod\'e1ln\'ed t\'f8\'eddou  0.25 \'b5
g/ml. Na marbofloxacin citliv\'fdch bylo 97.9% (92) izolovan\'fdch patogen\'f9 , 1 kmen bylo nutno za\'f8adit jako intermedi\'e1rn\'ec citliv\'fd  a 1 kmen  (1.1%) byl rezistentn\'ed. 
\par }\pard \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid3146785 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\cf9\insrsid14905235\charrsid11554319 
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 

\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 Bakterie mohou rozv\'edjet rezistenci proti fluorochinolon\'f9m p\'f8es tyto mechanismy:
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0\pararsid14905235 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 1/ }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid14905235\charrsid8665908 
Modifikace fluorochinolon\'f9 interakc\'ed}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435  \endash  inhibic\'ed ur\'e8it\'fdch bakteri\'e1ln\'edch topoi}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 z}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14905235\charrsid16535435 omer\'e1zov\'fdch enzym\'f9}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 , }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 zvl\'e1\'9at\'ec DNA gyr\'e1zy. Topoi}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14905235 z}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 omer\'e1zy jsou enzymy, kter\'e9 napadaj\'ed topologick\'e9 stadium DNA. DNA gyr\'e1za je slo\'9eena ze dvou podjednotek A a B.
\par -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 Mutace struktur\'e1ln\'edch gen\'f9 }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 pod}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14905235\charrsid16535435 jednotek DNA gyr\'e1zy (}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid14905235\charrsid10048313 gyr }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 A a }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\i\insrsid14905235\charrsid10048313 gyr}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435  B): zm\'ecny v\~}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid14905235\charrsid10048313 gyr}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14905235\charrsid16535435  B mohou ovlivnit rezistenci nep\'f8\'edmo p\'f8i zm\'ecn\'ec utv\'e1\'f8en\'ed }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid14905235\charrsid10048313 gyr}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 
 A, kter\'e1 je v\~domn\'ecl\'e9 vazb\'ec s\~chi}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 n}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 olony.
\par -}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 Mutace jin\'fdch topoi}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 z}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 omer
\'e1z, nap\'f8. nyn\'ed je zn\'e1mo, \'9ee topoi}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 z}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 omer\'e1za IV je sekund\'e1rn\'ed ter\'e8 c\'edl pro fluorochinolon}{\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid14905235 y}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 u kmen\'f9}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 \~}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 
\i\insrsid14905235\charrsid8665908 E.coli}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435  p\'f8i absenci citliv\'e9 DNA gyr\'e1zy.
\par 
\par 2/}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235  }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\insrsid14905235\charrsid8665908 Redukce intracelul\'e1rn\'ed akumulace:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435  Koncentrace }{\rtlch\fcs1 
\af0 \ltrch\fcs0 \insrsid14905235 \'fa\'e8inn\'e9ho }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid16535435 antibiotika}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235  v\~bakteri\'e1ln\'ed bu\'f2ce}{\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid14905235\charrsid16535435  m\'f9\'9ee b\'fdt redukov\'e1na}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235  prost\'f8ednictv\'edm:
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid3146785 \hich\af0\dbch\af0\loch\f0 -\tab}}\pard \ltrpar\s19\qj \fi-360\li720\ri0\widctlpar\jclisttab\tx720\wrapdefault\faauto\ls12
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst1\pnrxst0\pnrxst45\pnrxst0\pnrstop4\pnrstart1\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9\pnrstart2\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23
\pnrnfc23\pnrnfc23\pnrnfc0\pnrnfc0\pnrnfc4\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr4\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin720\itap0 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid14905235\charrsid3146785 pokles}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 u pr\'f9niku }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid3146785 antibiotika do bu\'f2ky }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid3146785 \hich\af0\dbch\af0\loch\f0 -\tab}}\pard \ltrpar\s19\qj \fi-360\li720\ri0\widctlpar\jclisttab\tx720\wrapdefault\faauto\ls12
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst1\pnrxst0\pnrxst45\pnrxst0\pnrstop4\pnrstart1\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9\pnrstart2\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23\pnrnfc23
\pnrnfc23\pnrnfc23\pnrnfc0\pnrnfc0\pnrnfc5\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr5\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin720\itap0 {\rtlch\fcs1 \af0 
\ltrch\fcs0 \insrsid14905235\charrsid3146785 vylu\'e8ov\'e1n\'ed antibiotika z}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235 \~}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235\charrsid3146785 bu\'f2ky}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid14905235  prost
\'f8ednictv\'edm effluxn\'edch pump
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 5.2. Farmakokinetick\'e9 \'fadaje
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Marbofloxacin se u psa a ko\'e8ky  po subkut\'e1nn\'ed aplikaci v doporu\'e8en\'e9 d\'e1vce 2-4 mg/kg \'9e.hm. rychle resorbuje a je 100% biologicky vyu\'9eiteln\'fd. Maxim\'e1ln\'ed koncentrace v\~plasm\'ec
 u obou druh\'f9 zv\'ed\'f8at p\'f8i subkut\'e1nn\'ed aplikaci d\'e1vky 2 mg/kg \'9e.hm. je 1,5 }{\rtlch\fcs1 \af45 \ltrch\fcs0 \f45\insrsid947691 \'ecg/ml a 3 \'ecg/ml p}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 \'f8i aplikaci d\'e1vky 4 mg/kg \'9e
.hm.  
\par Pouze nepatrn\'e1 \'e8\'e1st marbofloxacinu se v\'e1\'9ee na proteiny v\~plasm\'ec  (m\'e9n\'ec ne\'9e 10% u psa a ko\'e8ky). Velmi dob\'f8e je distribuov\'e1n  po cel\'e9m organismu. V\~hlavn\'edch tk\'e1n\'edch \endash  org\'e1nech (j\'e1tra, ledviny, k
\'f9\'9ee, svaly, pl\'edce, mo\'e8ov\'fd m\'ecch\'fd\'f8, za\'9e\'edvac\'ed trakt) je koncentrace marbofloxacinu vy\'9a\'9a\'ed ne\'9e-li v\~plasm\'ec.
\par Marbofloxacin se eliminuje pomaleji (polo\'e8as rozpadu je okolo 13 hodin), vylu\'e8uje se v\~aktivn\'ed form\'ec mo\'e8\'ed (2/3) a faeces (1/3). 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
\par 
\par 
\par 
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 \hich\af0\dbch\af0\loch\f0 6.\tab}}\pard \ltrpar\s19\qj \fi-480\li480\ri0\widctlpar\jclisttab\tx480\wrapdefault\faauto\ls7
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst2\pnrxst0\pnrxst0\pnrxst0\pnrxst46\pnrxst0\pnrstop6\pnrstart1\pnrrgb1\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9\pnrstart2\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0
\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc6\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr6\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrstop36\adjustright\rin0\lin480\itap0 {\rtlch\fcs1 
\ab\af0 \ltrch\fcs0 \b\insrsid947691 FARMACEUTICK\'c9 \'daDAJE
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 6.1 Seznam pomocn\'fdch l\'e1tek}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }\pard\plain \ltrpar\ql \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 
\fs24\ul\insrsid1248631\charrsid1248631 Lyofiliz\'e1t:
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 Mononatrium-edet\'e1t 
\par Benzalkonium chlorid
\par Manitol
\par Hydroxid sodn\'fd
\par }{\rtlch\fcs1 \af0\afs16 \ltrch\fcs0 \fs16\insrsid947691 
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\ul\insrsid1248631 Rozpou\'9at\'ecdlo}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\ul\insrsid947691 :
\par }{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 Voda na injekci
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 \hich\af0\dbch\af0\loch\f0 6.2\tab}}\pard\plain \ltrpar\s19\qj \fi-420\li420\ri0\widctlpar\jclisttab\tx420\wrapdefault\faauto\ls8\ilvl1
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst3\pnrxst0\pnrxst0\pnrxst0\pnrxst46\pnrxst0\pnrxst1\pnrxst0\pnrstop8\pnrstart1\pnrrgb1\pnrrgb3\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9
\pnrstart2\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc6\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc2\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr6\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr2\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrstop36\adjustright\rin0\lin420\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 Inkompatibilita 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Neuplat\'f2uje se.
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 6.3 Doba pou\'9eitelnosti
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Doba pou\'9eitelnosti veterin\'e1rn\'edho l\'e9\'e8iv\'e9ho p\'f8\'edpravku v\~neporu\'9aen\'e9m obalu: 3 roky
\par }\pard\plain \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 Doba pou
\'9eitelnosti po rozpu\'9at\'ecn\'ed nebo rekonstituci podle n\'e1vodu: 28 dn\'f9
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 

\par {\listtext\pard\plain\ltrpar \s19 \rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 \hich\af0\dbch\af0\loch\f0 6.4\tab}}\pard \ltrpar\s19\qj \fi-360\li360\ri0\widctlpar\jclisttab\tx360\wrapdefault\faauto\ls9\ilvl1
\pnrauth1\pnrdate1190511241\pnrstart0\pnrxst3\pnrxst0\pnrxst0\pnrxst0\pnrxst46\pnrxst0\pnrxst1\pnrxst0\pnrstop8\pnrstart1\pnrrgb1\pnrrgb3\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrrgb0\pnrstop9
\pnrstart2\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc6\pnrnfc0\pnrnfc0\pnrnfc0\pnrnfc4\pnrnfc0\pnrnfc0\pnrstop18\pnrstart3\pnrpnbr6\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr4\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0\pnrpnbr0
\pnrpnbr0\pnrstop36\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 Zvl\'e1\'9atn\'ed opat\'f8en\'ed pro uchov\'e1v\'e1n\'ed  
\par }\pard\plain \ltrpar\ql \li0\ri-318\widctlpar\wrapdefault\faauto\adjustright\rin-318\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 
Uchov\'e1vejte p\'f8i teplot\'ec do 25}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 {\field{\*\fldinst SYMBOL 176 \\f "Symbol" \\s 12}{\fldrslt\f3\fs24}}}{\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 C.
\par Chra\'f2te p\'f8ed sv\'ectlem.
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 

\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 6.5}{\rtlch\fcs1 \ab\af0\afs20 \ltrch\fcs0 \b\fs20\insrsid947691  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 Druh obalu a velikost balen\'ed}{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\ul\insrsid947691  

\par Lyofiliz\'e1t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691   - injek\'e8n\'ed lahvi\'e8ka }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11932807 z }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 hn\'ecd\'e9}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11932807 ho }{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 skl}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11932807 a t\'f8\'eddy}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  II, \'e8erven\'e1 chlorbutylov\'e1 gumovou z\'e1tka a hlin\'edkov\'e1 pertle 
\par }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\ul\insrsid11932807\charrsid11932807 Rozpou\'9at\'ecdlo}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 \endash  injek\'e8n\'ed lahvi\'e8ka}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11932807  z\~\'e8ir\'e9ho skla t\'f8\'eddy}{
\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  II, \'e8erven\'e1 chlorbutylov\'e1 gumovou z\'e1tka a hlin\'edkov\'e1 pertle
\par 
\par }{\rtlch\fcs1 \ai\af0 \ltrch\fcs0 \i\ul\insrsid947691 Velikost balen\'ed:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691   1 x lyofiliz\'e1t}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11932807  ({\*\xmlopen\xmlns2{\factoidname metricconverter}
{\xmlattr\xmlattrns0{\xmlattrname ProductID}{\xmlattrvalue 1 g}}}1 g{\*\xmlclose})}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  + 1 x }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid11932807 rozpou\'9at\'ecdlo }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 (20 ml)

\par                             
\par }\pard\plain \ltrpar\s1\ql \li0\ri0\keepn\widctlpar\wrapdefault\faauto\outlinelevel0\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \ab\af0\afs24\alang1025 \ltrch\fcs0 \b\fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 
\insrsid947691 6.6}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid947691  }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 Zvl\'e1\'9atn\'ed opat\'f8en\'ed pro zne\'9akod\'f2ov\'e1n\'ed nepou\'9eit\'e9ho veterin\'e1rn\'edho l\'e9\'e8iv\'e9ho p\'f8\'ed
pravku nebo odpadu, kter\'fd poch\'e1z\'ed z\~tohoto p\'f8\'edpravku}{\rtlch\fcs1 \ab0\af0 \ltrch\fcs0 \b0\insrsid947691 
\par }\pard\plain \ltrpar\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs20\alang1025 \ltrch\fcs0 \fs20\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0\afs24 \ltrch\fcs0 \fs24\insrsid947691 V\'9a
echen nepou\'9eit\'fd veterin\'e1rn\'ed l\'e9\'e8iv\'fd p\'f8\'edpravek nebo odpad, kter\'fd poch\'e1z\'ed z\~tohoto p\'f8\'edpravku, mus\'ed b\'fdt likvidov\'e1n podle m\'edstn\'edch pr\'e1vn\'edch p\'f8edpis\'f9.
\par }\pard\plain \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \fs24\lang1029\langfe1029\cgrid\langnp1029\langfenp1029 {\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 7.  DR\'8eITEL ROZHODNUT\'cd O REGISTRACI
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691 V\'e9toquinol s.r.o., Z\'e1me\'e8nick\'e1 411, CZ-288 02 Nymburk
\par }\pard \ltrpar\s19\qj \li360\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin360\itap0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\ul\insrsid947691 
\par }\pard \ltrpar\s19\qj \li0\ri0\widctlpar\wrapdefault\faauto\adjustright\rin0\lin0\itap0 {\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 8.  REGISTRA\'c8N\'cd \'c8\'cdSLO:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  96/020/03-C
\par 
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691 9.  DATUM REGISTRACE:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  19.3.2003
\par }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid947691      DATUM  PRODLOU\'8eEN\'cd  REGISTRACE:}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \b\insrsid7106053  }{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 \insrsid7106053\charrsid5795410 24.5.2011}{\rtlch\fcs1 \ab\af0 \ltrch\fcs0 
\b\insrsid947691 
\par 
\par 10.  DATUM POSLEDN\'cd REVIZE TEXTU:}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691  
\par }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid2824705 Kv\'ecten }{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid3146785\charrsid3146785 2011}{\rtlch\fcs1 \af0 \ltrch\fcs0 \insrsid947691\charrsid3146785 
\par }{\rtlch\fcs1 \af0\afs20 \ltrch\fcs0 \fs20\insrsid947691 
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